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	<title>Intelligent Design Exposed</title>
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	<description>Where the scientific vacuity of Intelligent Design is exposed from a Christian perspective</description>
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		<title>Intelligent Design Exposed</title>
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		<title>How to cook a graph in three easy lessons</title>
		<link>http://idexposed.wordpress.com/2008/05/22/how-to-cook-a-graph-in-three-easy-lessons/</link>
		<comments>http://idexposed.wordpress.com/2008/05/22/how-to-cook-a-graph-in-three-easy-lessons/#comments</comments>
		<pubDate>Thu, 22 May 2008 04:49:56 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
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		<description><![CDATA[Realclimate.org, a high quality science site, explains how to &#8220;cook a graph in three easy lessons&#8220;. In order to make the model look like the observations, the model had to assume a mixed layer depth of 1000m, when  a normal mixed layer depth is around 50m, depending on location, and time. 1000m is ludicrous indeed. [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=55&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>Realclimate.org, a high quality science site, explains how to &#8220;<a href="http://www.realclimate.org/index.php/archives/2008/05/how-to-cook-a-graph-in-three-easy-lessons/">cook a graph in three easy lessons</a>&#8220;. In order to make the model look like the observations, the model had to assume a mixed layer depth of 1000m, when  a normal mixed layer depth is around 50m, depending on location, and time. 1000m is ludicrous indeed.</p>
<blockquote><p>These days, when global warming inactivists need to trot out somebody with some semblance of scientific credentials (from the dwindling supply who have made themselves available for such purposes), it seems that they increasingly turn to Roy Spencer, a Principal Research Scientist at the University of Alabama.</p></blockquote>
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		<title>United Methodist Church: Evolution and Intelligent Design</title>
		<link>http://idexposed.wordpress.com/2008/05/19/united-methodist-church-evolution-and-intelligent-design/</link>
		<comments>http://idexposed.wordpress.com/2008/05/19/united-methodist-church-evolution-and-intelligent-design/#comments</comments>
		<pubDate>Mon, 19 May 2008 23:12:35 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
				<category><![CDATA[Uncategorized]]></category>

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		<description><![CDATA[The UMC seems to be in a pro-science mood when it passed resolution 80839 Evolution and Intelligent Design (80839-C1-R9999) Add a new resolution as follows: WHEREAS, the United Methodist Church has for many years supported the separation of church and State (paragraph 164, Book of Discipline, 2004, p. 119), THEREFORE BE IT RESOLVED that the [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=54&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>The UMC seems to be in a pro-science mood when it passed <a href="http://calms.umc.org/2008/Menu.aspx?type=Petition&amp;mode=Single&amp;number=839" target="_blank">resolution 80839</a></p>
<p><strong>Evolution and Intelligent Design (80839-C1-R9999)</strong></p>
<p>Add a new resolution as follows:</p>
<p><strong>WHEREAS, the United Methodist Church has for many years supported the separation of church and State (paragraph 164, Book of Discipline, 2004, p. 119),</strong></p>
<p><strong>THEREFORE BE IT RESOLVED that the General Conference of the United Methodist Church go on record as opposing the introduction of any faith-based theories such as Creationism or Intelligent Design into the science curriculum of our public schools.</strong></p>
<h2>Rationale</h2>
<p>Creationism and Intelligent Design are appropriate topics in public education classes such as comparative religion, literature, or philosophy since scientific method incorporates critical thinking processes.  All truth is God’s truth.   The promotion of religion or any particular religion in the public schools is contrary to the First Amendment.</p>
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		<title>United Methodist Church: An Apology for Support of Eugenics</title>
		<link>http://idexposed.wordpress.com/2008/05/19/united-methodist-church-an-apology-for-support-of-eugenics/</link>
		<comments>http://idexposed.wordpress.com/2008/05/19/united-methodist-church-an-apology-for-support-of-eugenics/#comments</comments>
		<pubDate>Mon, 19 May 2008 23:09:59 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
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		<description><![CDATA[The United Methodist Church has passed petition 81175 which expresses an apology for support of Eugenics Ironically, as the Eugenics movement came to the United States, the churches, especially the Methodists, the Presbyterians, and the Episcopalians, embraced it. Methodist churches around the country promoted the American Eugenics Society “Fitter Family Contests” wherein the fittest families [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=53&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>The United Methodist Church has passed petition 81175 which expresses <a href="http://calms.umc.org/2008/Menu.aspx?type=Petition&amp;mode=Single&amp;number=1175" target="_blank">an apology for support</a><a href="http://calms.umc.org/2008/Menu.aspx?type=Petition&amp;mode=Single&amp;number=1175"> of Eugenics</a></p>
<blockquote><p>Ironically, as the Eugenics movement came to the United States, the churches, especially the Methodists, the Presbyterians, and the Episcopalians, embraced it.<br />
Methodist churches around the country promoted the American Eugenics Society “Fitter Family Contests” wherein the fittest families were invariably fair skinned and well off. Methodist bishops endorsed one of the first books circulated to the US churches promoting eugenics. Unlike the battles over evolution and creationism, both conservative and progressive church leaders endorsed eugenics.  The liberal Rev. Harry F. Ward, professor of Christian ethics and a founder of the Methodist Federation for Social Service, writing in Eugenics, the magazine of the American Eugenic Society, said that Christianity and Eugenics were compatible because both pursued the “challenge of removing the causes that produce the weak. Conservative Rev. Clarence True Wilson, the General Secretary of the Methodist Episcopal Board of Temperance, Prohibition and Public Morals, and the man chosen to debate Clarence Darrow after William Jennings Bryan’s death, believed that only the white Aryan race was the descendent of the lost tribes of Israel.  Methodists were active on the planning committees of the Race Betterment Conferences held in 1914, and 1915.  In the 1910s, Methodist Churches hosted forums in their churches to discuss eugenics. In the 1920s, many Methodist preachers submitted their eugenics sermons to contests hosted by the American Eugenics Society.  By 1927, when the American Eugenics Society formed its Committee on the Cooperation with Clergymen, Bishop Francis McConnell, President of the Methodist Federation for Social Service served on the committee. In 1936, he would chair the roundtable discussion on Religion and Eugenics at the American Eugenics Society Meeting.  The laity of the church also took up the cause of eugenics. In 1929, the Methodist Review published the sermon “Eugenics: A Lay Sermon” by George Huntington Donaldson. In the sermon, Donaldson argues, “the strongest and the best are selected for the task of propagating the likeness of God and carrying on his work of improving the race.”<br />
Both the Methodist Episcopal Church and the Methodist Episcopal Church, South promoted eugenics.  Most of the time, church advocates of eugenics supported positive eugenics—essentially careful selection of mates. Nevertheless, sterilization became an acceptable kind of eugenics along with marriage laws limiting marriage between whites and non-whites. Some annual conferences supported such laws and a few opposed them.<br />
Indiana passed the first forced sterilization law in 1907; eventually 33 states passed similar laws.  Most used  Harry Laughlin’s model law that provided for the sterilization of “feeble minded, insane, criminalistic, epileptic, diseased, blind, deaf, deformed, and dependent” including “orphans, ne’er do wells, tramps, homeless, and paupers.” Virginia passed in 1924 a sterilization law based on the Laughlin model and on the same day passed a law making marriage between a white person and a non-white person a felony.<br />
Thirty-three US States eventually passed laws authorizing sterilization of criminals, the mentally ill, the “feeble minded”, Sterilization of the allegedly mentally ill continued into the 1970s in several states, by which time about 60,000 Americans had been involuntarily sterilized.  In 1933, Hitler’s Nazi government used Laughlin’s Model Law as the basis for their sterilization law that led to the sterilization of some 350,000 people.</p></blockquote>
<p>Note also that The Petition is amended as follows:</p>
<blockquote><p>
Delete everything from &#8220;we direct&#8230;&#8221; to the end of the petition.<br />
Change the title of Petition 81175 from &#8220;An Apology for Support of Eugenics&#8221; to:  <strong>&#8220;Repentance for Support of Eugenics&#8221; </strong>on both page 421 and 424.</p></blockquote>
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		<title>Pielke train wreck</title>
		<link>http://idexposed.wordpress.com/2008/05/19/pielke-train-wreck/</link>
		<comments>http://idexposed.wordpress.com/2008/05/19/pielke-train-wreck/#comments</comments>
		<pubDate>Mon, 19 May 2008 04:59:01 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
				<category><![CDATA[Global Warming]]></category>
		<category><![CDATA[Uncategorized]]></category>

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		<description><![CDATA[Tim Lambert at Deltoid discussed the train wreck surrounding Roger Pielke. Much of the similarities between ID Creationists and Global Warming Deniers like Pielke seem self evident, including a confidence not supported by the actual data that their side is correct. In the case of Pielke he confidently stated that the model predictions for the [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=52&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>Tim Lambert at Deltoid discussed the <a href="http://scienceblogs.com/deltoid/2008/05/pielke_train_wreck.php">train wreck</a> surrounding Roger Pielke. Much of the similarities between ID Creationists and Global Warming Deniers like Pielke seem self evident, including a confidence not supported by the actual data that their side is correct. In the case of Pielke he confidently stated that the model predictions for the global warming trend were not consistent with the actual data.</p>
<p>Of course, not only were the data consistent, but Pielke did not even know which statistical test to apply to show support for his thesis</p>
<p>And yet, there seem to be some people who have come to believe the arguments by Global Warming Deniers, and it should not come as too big a surprise that there is a significant overlap between those who support the scientifically vacuous position of Intelligent Design and Global Warming Deniers.</p>
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		<title>Robert Hazen: Origin of Life 101</title>
		<link>http://idexposed.wordpress.com/2008/05/14/robert-hazen-origin-of-life-101/</link>
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		<pubDate>Wed, 14 May 2008 03:26:22 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
				<category><![CDATA[Origin of Life]]></category>

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		<description><![CDATA[Robert Hazen is a research scientist at the Carnegie Institution of Washington&#8217;s Geophysical Laboratory and Clarence Robinson Professor of Earth Science at George Mason University. Robert Hazen is also author of &#8220;Intelligent Design and the College Science Classroom: Should We “Teach the Controversy?”&#8221; Hazen, R. M. Intelligent design and the college classroom: Should we &#8220;teach [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=26&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p style="padding-left:30px;"><a href="http://hazen.gl.ciw.edu/"><img class="alignleft" style="border:0 none;float:left;margin-left:4px;margin-right:4px;" src="http://www.gmu.edu/robinson/images/hazensm.jpg" alt="" width="35" height="50" />Robert Hazen</a> is a research scientist at the Carnegie Institution of Washington&#8217;s Geophysical Laboratory and Clarence Robinson Professor of Earth Science at George Mason University. Robert Hazen is also author of &#8220;Intelligent Design and the College Science Classroom: Should We “Teach the Controversy?”&#8221;  Hazen, R. M.  <strong>Intelligent design and the college classroom: Should we &#8220;teach the controversy&#8221;? </strong><em>Astrobiology</em> 6, 106. (2006)</p>
<blockquote><p>On the other hand, every student can benefit from an examination of the epistemological arguments that underlie this case. The fundamental distinction between science and religion as ways of knowing was central to the Dover case, and can serve to develop the critical thinking skills of all students.  Of special relevance is the exploration of “gaps” in our scientific understanding. ID proponents point to these gaps (leaps of “irreducible complexity”) in their invocation of a designer. Scientists, on the other hand, see such gaps as opportunities for further research and exploration, especially in instances of “emergent complexity,” such as the origin of life.</p>
<p><strong>05-14-2008: Note: During my final editing I switched from to an earlier version of the article and lost many edits. I have attempted to restore the article to its original state</strong>.</p>
<ul>
<li>“ID and the College Classroom: Should we ‘teach the controversy’?”. Presented several times during 2006-2007 as the Dover, Pennsylvania intelligent design trial evoked much debate. <a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/AbSciCon-ID.ppt">[PPT]</a></li>
<li>Achieving Scientific Literacy: A Catechism for Science Education Reform”. This is my basic lecture on how to design science courses for undergraduates who are not science majors. <a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/ScienceLiteracy.ppt">[PPT]</a></li>
</ul>
</blockquote>
<p style="padding-left:30px;"><span id="more-26"></span></p>
<p style="padding-left:30px;">There are many excellent resources available online and I recently ran across a conference organized by John C. Avise and Francisco J. Ayala called <a rel="external " href="http://www.nasonline.org/site/PageServer?pagename=SACKLER_evolution_program" target="_blank">In the Light of Evolution I: Adaptation and Complex Design</a></p>
<p style="padding-left:30px;">In the presentation that caught my initial interest, <a href="http://progressive.playstream.com/nakfi/progressive/Sackler/sackler_12-01_06_new/RobertHazen/RobertHazen.html">Hazen explains the various steps</a> necessary for the origin of life and defines complexity and shows how complexity can increase. I have combined notes on his lecture with additional papers and presentations by Hazen, in order to outline that which many creationists insist, does not exist: a scientific explanation of the origins of life.</p>
<p style="padding-left:30px;">I predict that ID creationists will be quick to argue that these are just so stories, and yet, these are stories which present testable hypotheses. And thus I invited ID creationists to present the best explanation as to how ID explains these data?</p>
<p style="padding-left:30px;">Seems fair enough.</p>
<p style="padding-left:30px;">Supporting slides can be found <a href="http://hazen.ciw.edu/sites/hazen.gl.ciw.edu/files/images/AbSciCon-ID.ppt">here</a>. In the presentation  he explains the various steps necessary for the origin of life and defines complexity and shows how complexity can increase.  The talk has two objectives</p>
<ol style="padding-left:30px;">
<li>Describe life&#8217;s origins in terms of a sequence of emergent processes</li>
<li>Propose a predictive, quantitative model of complex systems</li>
</ol>
<p style="padding-left:30px;">Three reasonable assumptions are made about the origin of life</p>
<ol style="padding-left:30px;">
<li>First life forms were carbon based</li>
<li>Life&#8217;s origin was a chemical process relying on water, air and rock (raw materials)</li>
<li>The origin of life required a sequence of emergent chemical steps of increasing complexity</li>
</ol>
<p style="padding-left:30px;">From the simplicity of a geochemical world to the complexity of a biochemical world</p>
<h2 style="padding-left:30px;">Emergence</h2>
<p style="padding-left:30px;">Emergent phenomena arise from the interactions among numerous agents. Their collective behavior is much greater than that of the individual particles. Examples include sand dunes, galaxies (spirals), ant colonies.</p>
<p style="padding-left:60px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/dunes.jpg?w=259&#038;h=263" alt="" width="259" height="263" /> <img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/spiral.jpg?w=250&#038;h=263" alt="" width="250" height="263" /></p>
<p style="padding-left:90px;"><em>Sand dunes and spiral galaxies: Natural emergent phenomena</em></p>
<p style="padding-left:30px;">And for example the slime mold, Dictyostelium which basic response to local chemical gradients results in complexity. Similarly, many individual neurons collectively form consciousness. Emergence happens at all scales: molecules, cells, organisms.</p>
<h2 style="padding-left:30px;">Origin of life in 4 steps</h2>
<p style="padding-left:30px;">Experimentally the origin of life is a tough problem so break it down</p>
<ol style="padding-left:30px;">
<li>Emergence of biomolecules</li>
<li>Emergence of organized molecular systems</li>
<li>Emergence of self-replicating molecular systems</li>
<li>Emergence of natural selection</li>
</ol>
<h2 style="padding-left:30px;">Emergence of biomolecules</h2>
<p style="padding-left:30px;">The first step is pretty easy: use simple molecules to build larger molecules. Start with water (H2O), CO2, volcanic gases&#8230; The Miller Urey experiment showed how simple processes can create molecules found in life such as amino-acids, sugars, lipids, nucleic acid bases. There are many ways to make simple organic molecules. Examples in nature include the  &#8220;dense molecular clouds&#8221;. These clouds are studied in NASA chambers with temperatures as low as 10K while UV radiation is added. The resulting chemicals eventually rain down on early earth. Other examples include black smokers, and the deep mantle. So how do we study the processes that take place in black smokers?</p>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Relevant PT articles</span></p>
<ul style="padding-left:30px;">
<li><a href="http://www.pandasthumb.org/archives/2007/04/primordial-soup.html">Primordial Soup&#8217;s On: Scientists Repeat Evolution&#8217;s Most Famous Experiment</a><br />
<blockquote class="kw-quote">
<div class="kw-quote-body">
<p><em>Bada discovered that the reactions were producing chemicals called nitrites, which destroy amino acids as quickly as they form. They were also turning the water acidic—which prevents amino acids from forming. Yet primitive Earth would have contained iron and carbonate minerals that neutralized nitrites and acids. So Bada added chemicals to the experiment to duplicate these functions. When he reran it, he still got the same watery liquid as Miller did in 1983, but this time it was chock-full of amino acids. Bada presented his results this week at the American Chemical Society annual meeting in Chicago.</em></p>
</div>
</blockquote>
</li>
</ul>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Hazen Powerpoint Lectures:</span></p>
<ul style="padding-left:30px;">
<li>What factors promote the emergence of biocomplexity”. This lecture was delivered at the first Kavli Futures Workshop (“From Nano to Bio”) in Ilulliset, Greenland (June 2007). <a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/KavliComplexity-13JUN07.ppt">[PPT]</a></li>
<li><span style="font-style:normal;font-variant:normal;font-weight:normal;font-size:7pt;line-height:normal;font-family:'Times New Roman';"> </span><!--[endif]-->“From Geo to Bio: The emergence of biochemical complexity”. This lecture was delivered as the NSF Biosciences Distinguished Lectureship presentation in June, 2007. [<a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/GeoToBio-NSF-18JUN07.ppt">PPT]</a></li>
<li>“Genesis: The scientific quest for life’s origins”. This lecture, based on my book of the same name, is aimed at a general audience and has been presented at many universities and public lecture series. <a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/Genesis-Brookings-15JUN07.ppt">[PPT]</a></li>
</ul>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Relevant Articles:</span></p>
<ul style="padding-left:30px;">
<li>H. James Cleaves, John H. Chalmers, Antonio Lazcano, Stanley L. Miller and Jeffrey L. BadaA Reassessment of Prebiotic Organic Synthesis in Neutral Planetary Atmospheres, 	<em>Origins of Life and Evolution of Biospheres</em>, Volume 38, Number 2, pp. 105-115 April, 2008</li>
</ul>
<p style="padding-left:60px;"><strong><span class="AbstractHeading">Abstract </span></strong>The action of an electric discharge on reduced gas mixtures such as H<sub>2</sub>O, CH<sub>4</sub> and NH<sub>3</sub> (or N<sub>2</sub>) results in the production of several biologically important organic compounds including amino acids. However, it is now          generally held that the early Earth’s atmosphere was likely not reducing, but was dominated by N<sub>2</sub> and CO<sub>2</sub>. The synthesis of organic compounds by the action of electric discharges on neutral gas mixtures has been shown to be much less efficient. We show here that contrary to previous reports, significant amounts of amino acids are produced from neutral gas mixtures. The low yields previously reported appear to be the outcome of oxidation of the organic compounds during hydrolytic workup by nitrite and nitrate produced in the reactions. The yield of amino acids is greatly increased when oxidation inhibitors, such as ferrous iron, are added prior to hydrolysis. Organic synthesis from neutral atmospheres may have depended on the oceanic availability of oxidation inhibitors as well as on the nature of the primitive atmosphere itself. The results reported here suggest that endogenous synthesis from neutral atmospheres may be more important than previously thought.</p>
<ul style="padding-left:30px;">
<li>Brandes, J.A., R.M. Hazen, H.S. Yoder, Jr., and G.D. Cody (2000) <strong>&#8220;Early pre- and post-biotic synthesis of alanine: an alternative to the Strecker synthesis.&#8221;</strong> In <em>Perspectives in Amino Acid and Protein Geochemistry</em>. (G.A. Goodfriend, M.J. Collins, M.L. Fogel, S.A. Macko, and J.F. Wehmiller, eds.). Oxford University Press, NY. pp. 41-59</li>
<li>Cody, G.D., R.M. Hazen, J.A. Brandes, H.J. Morowitz, H.S. Yoder, Jr. (2001) <strong>&#8220;Geochemical roots of autotrophic carbon fixation: Hydrothermal experiments in the system citric acid, H2O-(Â±FeS)-(Â±NiS).&#8221; </strong><em>Geochim. Cosmochim. Acta</em>, 65, 3557-3576.</li>
<li>Hazen, R.M. (2001) <strong>&#8220;Life&#8217;s rocky start.&#8221;</strong> <em>Scientific American</em>, 284, #4, 76-85.</li>
</ul>
<p style="padding-left:30px;">Take gold tube reactors, seal ingredients. Add high pressure and temperature and analyze.  Especially Carbon Carbon bonds: Small molecules become larger molecules through the addition of CH2 groups (Fisher- Tropsch (FT) synthesis). So let&#8217;s take CO2, H2 and H20, iron metal catalyst, 300C, 500 atm, 24 hrs.</p>
<p style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/slide212.jpg?w=720&#038;h=540" alt="FT Synthesis" width="720" height="540" /></p>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Relevant Publications </span> <a href="http://hazen.gl.ciw.edu/publications/astrobiology-and-origins">Hazen Publications</a></p>
<ul style="padding-left:30px;">
<li>Robert M Hazen et al <a href="http://www.iop.org/EJ/abstract/0953-8984/14/44/504">High pressure and the origin of life</a> 2002 J. Phys.: Condens. Matter 14 11489-11494</li>
<li> Cody et al <a href="http://www.liebertonline.com/doi/abs/10.1089/15311070152757519">Chemistry and Origins of Living Systems</a> Astrobiology. September 1, 2001, 1(3): 293-316.</li>
</ul>
<p style="padding-left:30px;">The results showed an &#8216;explosion&#8217; of molecules, not just chain molecules but also other products.</p>
<p style="padding-left:30px;">A similar process called Hydroformylation (add CO groups) is used to form carboxilic acid (important formetabolism). Now study FT and hydroformylation as function of minerals added. With cobalt and Nickel CO groups arise, FT synthesis happens almost everywhere. An &#8220;explosion&#8221; of molecules are generated in these vents.</p>
<p style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/slide24.jpg?w=720&#038;h=540" alt="" width="720" height="540" /> <img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/slide25.jpg?w=720&#038;h=540" alt="" width="720" height="540" /></p>
<h2 style="padding-left:30px;">Self assembling amphiphiles</h2>
<p style="padding-left:30px;">When amphiphiles are exposed to water, they are &#8216;forced&#8217; to form vesicles. So the question is: How to form such amphiphiles, since they self assemble into bilayer vesicles.</p>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Hazen Powerpoint Lectures:</span></p>
<ul style="padding-left:30px;">
<li><!--[endif]-->“Hydrothermal production of amphiphilic molecules from pyruvate.” Presented at the American Chemical Society Spring Meeting (San Diego, April, 2001). <a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/amphi.ppt">[PPT]</a></li>
</ul>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Relevant Articles:</span></p>
<p style="padding-left:30px;">Hazen, R.M. and D. Deamer (2006) <strong>&#8220;Hydrothermal reactions of pyruvic acid: synthesis, selection, and self-assembly of amphiphilic molecules.&#8221;</strong> <em>Origins of Life and Evolution of the Biosphere</em> 37, 143-152.</p>
<p style="padding-left:90px;"><strong>Abstract</strong> Selection and self-assembly of organic compounds in aqueous phases must have<br />
been a primary process leading to emergent molecular complexity and ultimately to the origin of<br />
life. Facile reactions of pyruvic acid under hydrothermal conditions produce a complex mixture<br />
of larger organic molecules, some of which are amphiphiles that readily self-assemble into cell-<br />
sized vesicular structures. Chemical characterization of major components of this mixture<br />
reveals similarities to the suite of organic compounds present in the Murchison carbonaceous<br />
chondrite, some of whose molecules also self-assemble into membranous vesicles. Physical<br />
properties of the products are thus relevant to understanding the prebiotic emergence of<br />
molecular complexity. These results suggest that a robust family of prebiotic reaction pathways<br />
produces similar products over a range of geochemical and astrochemical environments.</p>
<p style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/amphislide181.jpg?w=720&#038;h=540" alt="" width="720" height="540" /></p>
<h2 style="padding-left:30px;">Hydrothermal Production of Amphiphilic molecules form pyruvate</h2>
<p style="padding-left:30px;">Another experiment, this time with pyruvic acid at conditions mimicking hydrothermal environments.</p>
<h2 style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/amphislide17.jpg?w=720&#038;h=540" alt="" width="720" height="540" /></h2>
<p style="padding-left:30px;">Amphiphiles form which form vesicles</p>
<p style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/slide213.jpg?w=720&#038;h=540" alt="" width="720" height="540" /></p>
<h2 style="padding-left:30px;">Conclusions</h2>
<p style="padding-left:30px;">Similarities between our experimental products and Murchison meteorite organics suggest a similar robust polymerization chemistry.</p>
<h2 style="padding-left:30px;">Chirality</h2>
<p style="padding-left:30px;"><a href="http://en.wikipedia.org/wiki/Chirality_(chemistry)">Chirality</a> is important but what is chirality? Molecules have a &#8216;mirror&#8217; image which cannot be formed through rotation of the molecule. These are truly different forms, just like a right and left hand. When amino acids are formed, they typically occur in equal quantities of left and right handed forms and yet life as we know it is almost exclusively left handed.</p>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Relevant PT Articles</span></p>
<ul style="padding-left:30px;">
<li><a href="http://www.pandasthumb.org/archives/2006/06/chirality-of-li.html">Chirality of life: Another false positive?</a>
<ul>
<li>Chirality, the molecular version of right- and left-handedness, has intrigued chemists ever since Pasteur found mirror-image tartaric acid crystals. The synthesis of molecules in a single chiral form is usually achieved by using a chiral entity from the outset. But in some reactions the formation of a chiral product seems to be further amplified. Most current explanations implicate autocatalysis as the source of this asymmetry. An alternative mechanism is demonstrated this week. This new approach generates a strong bias towards one chiral form from a small initial imbalance, based on the equilibrium solid–liquid phase behaviour of amino acids. As this takes place in aqueous solution, the process might explain how a prebiotic world, with left- and right-handed molecules present in equal numbers, could turn into a living world where biomolecules favour one chiral form</li>
</ul>
</li>
<li><a href="http://www.pandasthumb.org/pt-archives/000295.html">The Left Hand of Darwin</a>
<ul>
<li>One long-standing question in understanding the origin of life is the so-called “<a href="http://www.answersingenesis.org/docs/3991.asp" target="_blank">chirality problem</a>”. While this is an unresolved question in our understanding of the origin of life, it is used by anti-evolutionists to beat evolutionary theory over the head. As we never tire of telling folk, the origin and subsequent evolution if life are two distinct issues.</li>
</ul>
</li>
</ul>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Hazen Powerpoints:</span></p>
<ul style="padding-left:30px;">
<li><span style="font-style:normal;font-variant:normal;font-weight:normal;font-size:7pt;line-height:normal;font-family:'Times New Roman';"> </span><!--[endif]-->“Right and Left: Mineral surfaces and the origin of biochemical homochirality”. Explores possible roles of chiral mineral surfaces in the selection and concentration of chiral amino acids and sugars. I’ve given this lecture many times during 2006-2007. <a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/Chirality-Embryology-26NOV07.ppt">[PPT]</a></li>
<li>“A combinatoric approach to the study of mineral-molecule interactions”. This lecture was delivered at the “Frontiers of Mineralogy” meeting in Cambridge England (June 2007) at a session I organized with Dimitri Sverjensky. <span class="feed_links">[<a href="http://hazen.gl.ciw.edu/sites/hazen.gl.ciw.edu/files/images/Frontiers2007.ppt">PPT]</a></span></li>
</ul>
<p style="padding-left:30px;"><span style="text-decoration:underline;">Relevant Articles:</span></p>
<ul style="padding-left:30px;">
<li>Hazen, R.M. and D.S. Sholl (2003b) <strong>&#8220;Origins of biomolecular homochirality: selective molecular adsorption on crystalline surfaces.&#8221;</strong> <em>Astrobiology</em> 2, 598-599.</li>
<li>Downs, R.T. and R.M. Hazen (2004) <strong>&#8220;Chiral indices of crystalline surfaces as a measure of enantioselective potential.&#8221;</strong> <em>Journal of Molecular Catalysis</em> 216, 273-285.</li>
<li>Hazen, R.M. (2004) <strong>&#8220;Chiral crystal faces of common rock-forming minerals.&#8221;</strong> In G. Palyi, C. Zucchi and L Cagglioti, Eds. <em>Progress in Biological Chirality.</em> New York: Elsevier, Chapter 11, pp.137-151.</li>
<li>Hazen, R.M. (2005) <strong><em>Genesis: The Scientific Quest for Life&#8217;s Origin.</em></strong> Washington, DC: Joseph Henry Press, 339 p.</li>
<li>Hazen, R.M. (2005) <strong>&#8220;Genesis: Rocks, minerals and the geochemical origin of life.&#8221;</strong> <em>Elements</em> 1, #3 (June, 2005), 135-137.</li>
<li>Hazen, R.M., T.R. Filley and G.A. Goodfriend (2001) <strong>&#8220;Selective adsorption of L- and D-amino acids on calcite: implications for biochemical homochirality.&#8221; </strong><em>Proceedings of the National Academy of Sciences</em> (US), 98: 5487-5490.</li>
<li>Asthagiri, A. and R.M. Hazen (2006) <strong>&#8220;An ab initio study of adsorption of alanine on the chiral calcite (2131) surface.&#8221;</strong> <em>Molecular Simulation</em> 33, 343-351</li>
<li>Asthagiri, A, and R. M. Hazen (2008) <strong>An <em>ab initio</em> study of adsorption of aspartic acid on the chiral calcite (2131) surface</strong>. In preparation.</li>
</ul>
<p style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/chiralslide10.jpg?w=720&#038;h=540" alt="" width="720" height="540" /></p>
<p style="padding-left:30px;">Chirality is important for life and medicine. Chiral impurities in <a href="http://en.wikipedia.org/wiki/Thalidomide">Thalidomide</a> which was used by pregnant women caused birth defects.</p>
<p style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/chiralslide14.jpg" alt="" /></p>
<p style="padding-left:30px;">So how do we go from a racemic mixture to a homochiral mixture? There are a variety of proposals and Hazen prefers minerals to explain symmetry breaking. Minerals have facets and different facets bind to either left or right-handed molecules</p>
<p style="padding-left:30px;">Hazen&#8217;s proposal</p>
<ol style="padding-left:30px;">
<li>Examine the occurrence of chiral mineral surfaces in nature (Hazen 2004; Downs &amp; Hazen 2004).</li>
<li>Demonstrate chiral selectivity by mineral surfaces (Hazen et al. 2001; Castro-Puyana et al. 2007).</li>
<li>Deduce mineral-molecule interactions (Asthagiri &amp; Hazen 2006; 2007).</li>
<li>Propose a general experimental research strategy (Hazen, Steele et al. 2005; Hazen 2006).</li>
</ol>
<p style="padding-left:30px;">His work concludes that</p>
<ul style="padding-left:30px;">
<li>Chiral mineral surfaces are common.</li>
<li>In oxides and silicates, larger chiral indices are often associated with the presence of both terminal cations and anions.</li>
<li>Relatively large chiral indices are often associated with stepped and kinked surfaces.</li>
<li>Calcite (214) crystal surfaces select D- and L-aspartic acid.</li>
<li>They  did not observe selective adsorption of glutamic acid or alanine on calcite.</li>
<li>Maximum selective adsorption occurs on terraced crystal faces. This fact suggests that chiral selection may occur along linear features.</li>
<li>The alignment of chiral amino acids on calcite may lead to homochiral polymerization.</li>
</ul>
<h3 style="padding-left:30px;">A combinatoric problem</h3>
<p style="padding-left:30px;">How do we evaluate interactions among the numerous possible mineral-molecule pairs? We need a combinatoric approach. Automation using microarrays.</p>
<p style="padding-left:30px;"><img class="alignleft" style="float:left;" src="http://idexposed.files.wordpress.com/2008/05/ciralslide59.jpg?w=300&#038;h=200" alt="" width="300" height="200" /><img class="alignright" style="float:right;" src="http://idexposed.files.wordpress.com/2008/05/chiralslide60.jpg?w=300&#038;h=200" alt="" width="300" height="200" /></p>
<h2 style="padding-left:30px;">Conclusions</h2>
<p style="padding-left:30px;">Many mineral surfaces have the potential for chiral selection of plausible prebiotic molecules.<br />
Chirality problem &#8211; Calcite (lime stone, coral reefs) has wonderful chiral surfaces allowing left and right handed molecules to be separated.</p>
<h2 style="padding-left:30px;">Self replication and natural selection</h2>
<p style="padding-left:30px;">Self replicating groups of molecules Kauffman or networks of molecules becomes self perpetuating (Kauffman, Packard 1986) or  Morowitz&#8217;s TCA cycle (citric acid). DNA world was likely preceeded by an RNA world: first self replicating molecule was a genetic polymer (and catalyst). RNA  construction in prebiotic world is however implausible and requires a preceding stage (PAH world, Lipid world)</p>
<h3 style="padding-left:30px;">Emergence of natural selection</h3>
<p style="padding-left:30px;">Self replicating system, add mutations, add competition, and selection follows. Transition from non-living to living systems.</p>
<p style="padding-left:30px;">Szostak lab. Start with random sequences of RNA, in vitro process, remove non-binding strands, collect bound RNA, PCR amplify with errors, transcribe DNA to new RNA, repeat. Strands evolve to become well adapted. RNA Aptamer work.</p>
<h2 style="padding-left:30px;">Complexity defined</h2>
<p style="padding-left:30px;">Need for quantitative models of complex systems Universal metric: Complexity is hard to define, depends on context. Complexity at many different scales and dimensionalities. Key to defining complexity is not structure but function. Szostak: Functional information: I as the fraction of configurations of a system [F(E)] that achives a specific degree of function (E)</p>
<p style="text-align:center;padding-left:30px;">I(E) = -log(2) [(F(E)]</p>
<p style="padding-left:30px;">Multiple functions means multiple values for I depending on functions  Apply metric: How to test this? Lots of sequences and define the degree of function of those sequences. Use Avida (artificial life). Random Avido genomes from the set of 26 instructions. A small fraction will have one or more logic functions.</p>
<p style="padding-left:30px;">How to increase Complexity</p>
<ol style="padding-left:30px;">
<li>Increase the number of interacting agents.</li>
<li>Increase the diversity of interacting agents.</li>
<li>Increase selective pressures by environmental cycling</li>
</ol>
<p style="padding-left:30px;">Relevant Articles</p>
<ul style="padding-left:30px;">
<li>Hazen, R.M., P.L. Griffin, J.M. Carothers and J.W.Szostak (2007) <strong><a href="http://www.pnas.org/cgi/content/full/104/suppl_1/8574">Functional information and the emergence of biocomplexity</a>.</strong> <em>Proceedings of the National Academy of Sciences USA</em> 104, 8574-8581.</li>
<li>Hazen, R. M. (2007) <strong>The emergence of chemical complexity: An Introduction.</strong> In L. Zaikowski and J. M. Friedrich [editors], <em>Chemical Evolution I: Chemical Change across Space and Time</em>. American Chemical Society Symposium, pp.2-14.</li>
</ul>
<p style="padding-left:30px;">Quantify complexity using Avida.  Use the following &#8216;phenotypes&#8217;: Addition, subtraction, NOT, NAND, ORN, OR, ANDN, NOR, XOR and EQU  How many of one task exist ? How many of any task? How many different tasks?</p>
<p style="padding-left:30px;">Using 300 command Avida genomes and 10^7 trials, NAND function appears in 1 out of every 1000 genomes. We see gaps, gaps in the same spots. Sometimes random outliers. When we use different length genomes, we observe different gaps and outliers. Why do these gaps exist? Is there a Universal characteristics?</p>
<p style="padding-left:30px;"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/picture-3.png?w=625&#038;h=477" alt="" width="625" height="477" /></p>
<p style="padding-left:90px;">Distribution of the not/and (NAND) function in 300-line Avida genomes in a randomly generated sample of 107 genomes. The degree of function, E, is the number of times NAND is executed by the genome, whereas functional information, I (in bits), is -log2 of the fraction of all sequences that achieves at least that degree of function, F(E). Note the discontinuities, which are a recurrent feature in these experiments.</p>
<p style="padding-left:90px;">
<p style="padding-left:120px;"><img src="http://idexposed.files.wordpress.com/2008/05/picture-4.png?w=235&#038;h=175" alt="" width="235" height="175" /><img src="http://idexposed.files.wordpress.com/2008/05/picture-5.png?w=300&#038;h=175" alt="" width="300" height="175" /></p>
<p style="padding-left:120px;"><strong>LEFT</strong> <em>The frequency of the ADD function in 100-, 200-, 300-, and 500-line linear Avida genomes in randomly generated samples of 10<sup>6</sup> genomes. Degree of function, </em><em>E, is the number of times the ADD function is executed by the genome, whereas functional information, </em><em>I (in bits), is –log<sub>2</sub> of the fraction of all sequences that achieves at least that degree of function, </em><em>F(</em><em>E). Note that maximum </em><em>E increases with genome length.</em></p>
<p style="padding-left:120px;"><strong>RIGHT</strong> <em>Schematic representation of four discrete functional classes, or &#8220;islands,&#8221; of solutions that display function. The vertical axis is degree of function, E, whereas the horizontal plane represents a two-dimensional projection in sequence space. The number of sequences with degree of function <img src="http://www.pnas.org/math/ge.gif" border="0" alt="≥" /></em><em>E</em> corresponds to the area intersected by the horizontal plane at that height along the <em>E axis. Increasing </em><em>E</em> above the heights of the flat-topped islands A and B will result in discontinuities in the function <em>E</em> versus <em>I, as illustrated in <a href="http://www.pnas.org/cgi/content/full/104/suppl_1/8574#F1">Figs. 1</a> and <a href="http://www.pnas.org/cgi/content/full/104/suppl_1/8574#F2">2</a>. Island C is a cone-shaped distribution, and island D represents a discrete solution of the type that might not be discovered in random sampling experiments.</em></p>
<p style="padding-left:30px;">Observation: Sand dunes form at a critical density. Galaxies spiral arms at critical density. Swarm raiding ants require a critical number before they start their raids. Many reactions such as  vesicle formation, condensation reactions all have critical number. The Concentration of agents is important.</p>
<p style="padding-left:30px;">Example for Avida</p>
<p style="padding-left:30px;">Start with highly functional genome 73 subtractions. Test every point mutation. Impact on functionality. 93% are neutral, tiny fraction lead to higher functionality, larger fraction detrimental.</p>
<h2 style="padding-left:30px;">Proposal</h2>
<p style="padding-left:30px;">Optimize experiments in origins of life. This means that molecular concentrations are essential. And &#8216;messy&#8217; experiments may promote emergence (more interacting players) Design experiments that mimic environmental cycles since such cycling environmental conditions (wet/dry, free/thaw, etc)  lead to complexity.</p>
<p style="padding-left:30px;">Explore more resources, courtesy of Robert Hazen</p>
<ul style="padding-left:30px;">
<li><a href="http://hazen.gl.ciw.edu/publications/astrobiology-and-origins">Publications</a> <a href="http://hazen.gl.ciw.edu/node/195">Lecture PowerPoint Presentations of Recent Lectures</a></li>
<li><a href="http://hazen.gl.ciw.edu/node/192">Lecture Abstracts and PowerPoint Presentations </a></li>
</ul>
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		<title>On the Chemical Constitutuents of the Seeds of Datura Stramonium</title>
		<link>http://idexposed.wordpress.com/2008/05/13/on-the-chemical-constitutuents-of-the-seeds-of-datura-stramonium/</link>
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		<pubDate>Tue, 13 May 2008 17:25:28 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
				<category><![CDATA[Uncategorized]]></category>

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		<description><![CDATA[Every now and then, while doing research, one runs into little gems of history. In the case of Datura Stramonium, I found a thesis by Isao Nishimura at the University of Wisconsin dated 1922. The thesis contains meticulous descriptions of experiments conducted to unravel the mysteries of Datura Stramonium. The researcher prepared some microscopic drawings [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=41&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>Every now and then, while doing research, one runs into little gems of history. In the case of Datura Stramonium, I found a thesis by Isao Nishimura at the University of Wisconsin dated 1922. The thesis contains meticulous descriptions of experiments conducted to unravel the mysteries of Datura Stramonium.</p>
<p>The researcher prepared some microscopic drawings of the seeds, pointing out that earlier researchers had stated that the alkaloids were present in the outer layer, and that the endosperm and the embryo are free from alkaloids, although one researcher reported trace amounts of alkaloids.</p>
<p>To detect the presence of alkaloids a solution of iodine in potassium iodide was used to stain the alkaloids, even though it also reacts with starches.</p>
<p>Visual inspection showed that the endosperm and the embryo were wholly free of staining, showing the absence of alkaloids in these parts of the seeds.</p>
<p>The thesis also discusses the oils extracted from mature and immature seeds, observing that the former were yellowish in colour while the latter one was dark green.</p>
<p><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/seed_stramonium.jpg?w=455&#038;h=683" alt="" width="455" height="683" /></p>
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		<title>Target Atmospheric CO2: Where Should Humanity Aim?</title>
		<link>http://idexposed.wordpress.com/2008/05/12/target-atmospheric-co2-where-should-humanity-aim/</link>
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		<pubDate>Mon, 12 May 2008 20:04:43 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
				<category><![CDATA[Global Warming]]></category>
		<category><![CDATA[CO2]]></category>
		<category><![CDATA[Hansen]]></category>

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		<description><![CDATA[I have found that the same ignorance that surrounds evolutionary theory extends often to the issue of Global Warming. James Hansen et al have released a report outlining the case for CO2 Paleoclimate data show that climate sensitivity is ~3°C for doubled CO2, including only fast feedback processes. Equilibrium sensitivity, including slower surface albedo feedbacks, [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=30&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>I have found that the same ignorance that surrounds evolutionary theory extends often to the issue of Global Warming.</p>
<p>James Hansen et al have released a report outlining the case for CO2</p>
<blockquote><p>Paleoclimate data show that climate sensitivity is ~3°C for doubled CO2, including only fast feedback processes. Equilibrium sensitivity, including slower surface albedo feedbacks, is ~6°C for doubled CO2 for the range of climate states between glacial conditions and icefree Antarctica. Decreasing CO2 was the main cause of a cooling trend that began 50 million years ago, large scale glaciation occurring when CO2 fell to 425±75 ppm, a level that will be exceeded within decades, barring prompt policy changes. If humanity wishes to preserve a planet similar to that on which civilization developed and to which life on Earth is adapted, paleoclimate evidence and ongoing climate change suggest that CO2 will need to be reduced from its current 385 ppm to at most 350 ppm. The largest uncertainty in the target arises from possible changes of non-CO2 forcings. An initial 350 ppm CO2 target may be achievable by phasing out coal use except where CO2 is captured and adopting agricultural and forestry practices that sequester carbon. If the present overshoot of this target CO2 is not brief, there is a possibility of seeding irreversible catastrophic effects.</p>
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<p>Read more at <a href="http://gristmill.grist.org/story/2008/4/7/0330/88509">350ppm or bust</a></p>
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		<title>Plants that defy evolution:  Datura stramonium (Jimson Weed)</title>
		<link>http://idexposed.wordpress.com/2008/05/11/plants-that-defy-evolution-datura-stramonium-jimson-weed/</link>
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		<pubDate>Sun, 11 May 2008 22:32:48 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
				<category><![CDATA[Intelligent Design]]></category>
		<category><![CDATA[Scientific Vacuity]]></category>
		<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[co-evolution]]></category>
		<category><![CDATA[Plant]]></category>

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		<description><![CDATA[Some creationists consider the thorns on plants a problem for evolutionary theory. As I will show, this is based on a flawed understanding of evolutionary theory. But before I proceed, let me present the &#8216;argument&#8216; presented by Joseph Alden (uncle of  Gary McGuire) The &#8216;argument&#8217; Per your request, I am forwarding two more examples of [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=28&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p>Some creationists consider the thorns on plants a problem for evolutionary theory. As I will show, this is based on a flawed understanding of evolutionary theory. But before I proceed, let me present the &#8216;<a href="http://evolution-facts.org/New-material/Alden%27s.htm">argument</a>&#8216; presented by Joseph Alden (uncle of  Gary McGuire)</p>
<h1><span id="more-28"></span>The &#8216;argument&#8217;</h1>
<blockquote><p>Per your request, I am forwarding two more examples of plant species, which DEFY Darwinian evolution.</p>
<p>Examples :</p>
<p>1.  The &#8221; jimson weed &#8220;</p>
<p>Scientific name : <em> Datura stramonium</em>.   This is a basic plant that grows wild, like most other weeds, namely in various parts of the United States.  However, this weed is toxic.  Its roots, stems and leaves all contain trace amount of natural poisons,  including several alkaloid compounds.   And yet, the  MOST  toxic area of the plant is found in the seed pod.  This pod is about the size of a walnut and is covered with prickly thorns.  Why all the thorns ?   They serve NO practical purpose in the growth of the plant, at any stage in its life cycle.    Therefore, why the need for all these thorns, located around a pod of toxic seeds ?  Does the plant KNOW it is lethal ?<br />
IMPOSSIBLE.    It is a  PLANT .    It has no brain, no central nervous system, no subjective thought process, etc.  Why then,  would it have added this feature at some point in time, according to evolutionists,  and established for itself all these thorns, that serve no purpose in the growth of the plant ?   Its contents, by the way are NOT lethal to other plants; only animals.  Therefore, could plants know that animals are looming about ?   NO.  Again, it is impossible !  They have no ability for any analytical thought process.  They also have no sensory perception, like animals, so they would not know of potential danger from its toxic seeds.   How and why would it possess this defense mechanism ?</p>
<p>Easy.  The plant was  CREATED  by an intelligent designer from the start.  Why you ask ?    Simple.  There IS a benefit to all those toxic seeds.  They have been used for medicinal purposes for years.  It&#8217;s just that, in mass quantity, if consumed by wild animals or humans, they could be potentially fatal.  Thus, Creationists can easily explain, through basic scientific observation, the existence of the jimson weed.  Evolutionists  hate examples, like the jimson weed, because it DISPROVES the deductive reasoning used  to justify evolution.</p></blockquote>
<h1>The scientific explanation</h1>
<p>Let&#8217;s now see how science explains the origin and evolution of thorns and why there are plants which have thorns protecting the seed pods when the seeds themselves are toxic.</p>
<h2>Co-evolution in plants</h2>
<p>A good review paper of coevolution of defenses in plants is found in Rausher&#8217;s <a href="http://www.biology.duke.edu/rausher/evgen/reprints/Nature2001.pdf"> Co-evolution and plant resistance to natural enemies </a> published in Nature,  vol. 411, Jun 2001. We have to remember that there are a variety of potential selective pressures that may guide the evolution of these defenses, that this is a process of co-evolution and that this is a process involving a variety of predators and threats. As I will show the answer to the &#8220;paradox&#8221; can be easily found when taking into account these issues. Plants have evolved an arsenal of defenses which include <strong>resistance </strong>through chemical defensive (for instance alkaloids),  induced defenses, and morphological defenses (trichomes (hairs and thorns), cell walls, etc ). Chemical defenses are typically seen as having evolved from metabolic by-products. In addition to <strong>resistance</strong>, plants also have developed <strong>tolerance</strong> as an effective co-evolutionary response. <strong>Tolerance</strong> reduces or eliminates the detrimental effect of damage or infection to the plant. Plants also deploy <strong>avoidance</strong> even though the plant is not mobile through for instance <em>cryptic coloration</em>.</p>
<p style="text-align:center;"><img class="aligncenter" style="vertical-align:middle;" src="http://icb.oxfordjournals.org/content/vol43/issue3/images/large/i1540-7063-043-03-0408-f01.jpeg" alt="" width="450" height="175" /></p>
<p style="text-align:left;padding-left:90px;"><em>The phenotypic interface of coevolution. Fitness of each individual involved in interspecific interactions is determined through reciprocal selection both caused and experienced by the phenotypes that mediate the interaction. This phenotypic interface typically involves performance traits that comprise a variety of behavioral, morphological, and physiological components (from <a href="http://icb.oxfordjournals.org/cgi/content/full/43/3/408">Reciprocal Selection at the Phenotypic Interface of Coevolution</a>)<br />
</em></p>
<p>Second of all, plants have been shown to be &#8216;jack of all trades&#8217;</p>
<blockquote><p>Overall, our survey provides little evidence that genetic trade-offs between defensive traits signiﬁcantly constrain the evolution of multiple defenses. To a large extent, plants appear to be jacks-of-all-trades, masters of all: they may successfully produce several types of defense without paying considerable trade-offs. Therefore, the original view that multiple defenses are costly and functionally redundant should be replaced by the idea that environmental variability and positive interactions among defenses can make many combinations of defenses possible and evolutionarily advantageous.</p></blockquote>
<p style="padding-left:30px;">Julia Koricheva, Heli Nykanen, and Ernesto Gianoli <strong>Meta-analysis of Trade-offs among Plant Antiherbivore  Defenses: Are Plants Jacks-of-All-Trades, Masters of All?</strong> <em>The American Naturalist </em>vol. 163 , no . 4 , April 2004</p>
<p>So let&#8217;s see how we can explain the &#8216;paradox&#8217; of <em>Datura Stramonium</em>, aka the Jimson Weed</p>
<h2>Datura Stramonium (Jimson Weed)</h2>
<p>First the origin of the common name Jimson Weed can be <a href="http://waynesword.palomar.edu/ww0703.htm#Datura">traced back to 1676</a></p>
<blockquote><p>Although jimsonweed is synonymous with several species of Datura, this unusual common name is actually derived from D. stramonium. In 1676 British soldiers stationed in Jamestown, Virginia became intoxicated by D. stramonium when it was inadvertently included in their salads by the regimental cooks. The episode was widely publicized and the plant culprit became known as &#8220;Jamestown weed&#8221;, and later as jimsonweed.</p></blockquote>
<p>The seeds, leaves, stem, roots and fruits all contain a variety of chemicals</p>
<blockquote><p>The leaves, stem, root and fruits of Datura contain a battery of tropane alkaloids, the most potent of which are atropine, hyoscyamine and scopolamine. These alkaloids affect the central nervous system, including nerve cells of the brain and spinal cord which control many direct body functions and the behavior of men and women. They may also affect the autonomic nervous system, which includes the regulation of internal organs, heartbeat, circulation and breathing. One autonomic response of atropine is the dilation of pupils, once considered to be a beautiful and mysterious look in Italian women. In fact, belladonna means &#8220;beautiful lady,&#8221; so named because sap from the closely related belladonna plant (Atropa belladonna) was used as eye drops to dilate the pupils.</p></blockquote>
<p>In addition to being used as hallucinogens during religious ceremonies, or as sexual stimulants by prostitutes, or as anesthetics (novocain) or as a drug against motion sickness. One may very well conclude that the &#8216;designer&#8217; surely had a wide range in applications in mind while creating these drugs&#8230;</p>
<p>First of all let&#8217;s describe <a href="http://plants.usda.gov/java/nameSearch?keywordquery=Datura+stramonium&amp;mode=sciname&amp;submit.x=25&amp;submit.y=9">Datura stramonium</a></p>
<p><img style="vertical-align:middle;" src="http://plants.usda.gov/gallery/standard/dast_002_shp.jpg" alt="" width="330" height="220" /></p>
<p><span class="sm">©Patrick J. Alexander. Provided by <a class="sm" href="http://www.polyploid.net/" target="_blank">Patrick J. Alexander</a>. </span></p>
<p>As you can observe, the seed pods are protected by thorns and yet, the seeds themselves are toxic to mammals although cattle is known, under stress, to eat the weeds.</p>
<p><span class="hdrblkbold">Classification:</span><br />
<span class="search"><em>Datura</em> <em>stramonium</em> L.</span></p>
<table border="0" cellspacing="1" cellpadding="1">
<tbody>
<tr>
<td></td>
<td></td>
</tr>
<tr class="rowon">
<td class="classind0" width="35%" scope="row">Kingdom</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Plantae&amp;display=63"><em>Plantae</em></a> – Plants</td>
</tr>
<tr class="rowon">
<td class="classind1" width="35%" scope="row">Subkingdom</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Tracheobionta&amp;display=63"><em>Tracheobionta</em></a> – Vascular plants</td>
</tr>
<tr class="rowon">
<td class="classind2" width="35%" scope="row">Superdivision</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Spermatophyta&amp;display=63"><em>Spermatophyta</em></a> – Seed plants</td>
</tr>
<tr class="rowon">
<td class="classind3" width="35%" scope="row">Division</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Magnoliophyta&amp;display=63"><em>Magnoliophyta</em></a> – Flowering plants</td>
</tr>
<tr class="rowon">
<td class="classind4" width="35%" scope="row">Class</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Magnoliopsida&amp;display=63"><em>Magnoliopsida</em></a> – Dicotyledons</td>
</tr>
<tr class="rowon">
<td class="classind5" width="35%" scope="row">Subclass</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Asteridae&amp;display=63"><em>Asteridae</em></a></td>
</tr>
<tr class="rowon">
<td class="classind6" width="35%" scope="row">Order</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Solanales&amp;display=63"><em>Solanales</em></a></td>
</tr>
<tr class="rowon">
<td class="classind7" width="35%" scope="row">Family</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=Solanaceae&amp;display=63"><em>Solanaceae</em></a> – Potato family</td>
</tr>
<tr class="rowon">
<td class="classind8" width="35%" scope="row">Genus</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=DATUR&amp;display=63"><em>Datura</em> L.</a> – jimsonweed</td>
</tr>
<tr class="rowon">
<td class="classind9" width="35%" scope="row">Species</td>
<td><a href="http://plants.usda.gov/java/ClassificationServlet?source=profile&amp;symbol=DAST&amp;display=63"><em>Datura</em> <em>stramonium</em> L.</a> – jimsonweed</td>
</tr>
</tbody>
</table>
<p>The Family Solanaceae contains potatoes, eggplant, tobacco as well as nightshade. Another data point: Jimson Weed like most of its family members have been imported from tropical areas. Note that the toxicity of the Jimson Weed is not limited to the seed pods, but includes the leaves, stem, and other parts of the plant. This is important when discussing the relevance of toxic defenses against herbivore insects.</p>
<h2>The hypothesis</h2>
<p>So now the evolutionary hypothesis</p>
<blockquote>
<p class="lead">Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth&#8217;s biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this similarity, the investigation of resistance mechanisms in crops is helping to elucidate the workings of co-evolution in nature, while evolutionary principles, including those derived from investigation of co-evolution in nature, are being applied in the management of resistance in genetically engineered crops.</p>
</blockquote>
<p style="padding-left:30px;">review article <strong>Co-evolution and plant resistance to natural enemies</strong><em> Nature</em> <strong>411</strong>, 857-864 (14 June 2001)</p>
<p>Thus, in order to understand the evolution of <em>Datura Stramonium</em>, we have to understand its evolutionary history, the original environment(s) in which this evolution took place, and the selective pressures that existed and the genetic variation. In addition we need to show that there are selectable, inheritable traits.</p>
<p>In other words, ecology and molecular biology all need to work together to establish answers to these questions.</p>
<h2>Evolution of mixed strategies</h2>
<blockquote>
<p class="abstract">In this study we present a simple optimization model for the evolution of defensive strategies (tolerance and resistance) of plants against their natural enemies. The model specifically evaluates the consequences of introducing variable costs and benefits of tolerance and resistance and nonlinear cost-and-benefit functions for tolerance and resistance. Incorporating these assumptions, the present model of plant defense predicts different evolutionary scenarios, not expected by previous work. Basically, the presence of an adaptive peak corresponding to intermediate levels of allocation to tolerance and resistance can arise when the shape parameter of the cost function is higher than the corresponding of the benefit function. The presence of two alternatives peaks of maximum tolerance and maximum resistance occurs only when benefits of tolerance and resistance interact less than additive. Finally, the presence of one peak of maximum resistance or maximum tolerance depends on the relative values of the magnitude of costs for tolerance and resistance. An important outcome of our model is that under a plausible set of conditions, variable costs of tolerance and resistance can represent an important aspect involved in the maintenance of intermediate levels of tolerance and resistance, and in favoring adaptive divergence in plant defensive strategies among populations. The model offers a framework for future theoretical and empirical work toward understanding spatial variation in levels of allocation to different defensive strategies.</p>
</blockquote>
<p style="padding-left:30px;"><strong>EVOLUTION OF MIXED STRATEGIES OF PLANT DEFENSE ALLOCATION AGAINST NATURAL ENEMIES,</strong> <em>Evolution</em>, Volume 58, Issue 8 (August 2004)</p>
<p>As such we come to realize that herbivores included both the grazing types (mammals) as well leaf eating types (herbivorous insects).</p>
<p>Thus we need to explain how alkaloid content (the poisonous part of Jimson Weed) is under selective pressure from insect herbivory and how thorns can be both under selective pressures from insect and grazing mammals.</p>
<h2>Insect Herbivory and alkaloid content</h2>
<p>The first step is to link alkaloid content to insect herbivory.</p>
<blockquote><p><span class="inline_heading_h4"><strong>Abstract</strong>.—</span>Although insect herbivory is frequently assumed to be responsible for the maintenance of plant secondary metabolites such as alkaloids, the assumption is controversial and experimental evidence for this assumption is sparse. We examined natural selection on the two major alkaloids present in the leaves of <em>Datura stramonium</em> and found that both alkaloids came under active selection. We found negative directional selection for scopolamine (natural selection acting to reduce scopolamine levels) and stabilizing selection for hyoscyamine (natural selection acting to maintain an intermediate level of hyoscyamine). We also present evidence that insect herbivores act as the agents of selection on these alkaloids. Finally, we show that there were no trade-offs in resistance to different species of insects.</p></blockquote>
<p style="padding-left:30px;">Irene Shonle, Joy Bergelson (2000) <strong>EVOLUTIONARY ECOLOGY OF THE TROPANE ALKALOIDS OF DATURA STRAMONIUM L. (SOLANACEAE)</strong> <em>Evolution</em> 54 (3) , 778-788</p>
<p>See also the <a href="http://scholar.google.com/scholar?hl=en&amp;lr=&amp;client=firefox-a&amp;cites=5806383510653834565">various references to the above paper</a></p>
<h2>Trichome defense and resistance to herbivorous insects</h2>
<p>Then there is <a href="http://en.wikipedia.org/wiki/Trichome">Trichome</a> and thorn production. Trichromes are &#8220;<a href="http://jxb.oxfordjournals.org/cgi/content/full/51/344/497">any protrusion from the epidermis</a>&#8220;  and include hairs as well as thorns. For<em> Datura Stramonium</em>, trichromes have been shown to be under selective pressure against insects.</p>
<blockquote><p>This study assessed the role of leaf trichome density as a component of resistance to herbivores, in six populations of <em>Datura stramonium</em>. Phenotypic selection on plant resistance was estimated for each population. A common garden experiment was carried out to determine if population differences in leaf trichome density are genetically based. Among population differences in leaf trichome density, relative resistance and fitness were found. Leaf trichome density was strongly positively correlated to resistance across populations. In 5 out of 6 populations, trichome density was related to resistance, and positive directional selection on resistance to herbivores was detected in three populations. Differences among populations in mean leaf trichome density in the common garden suggest genetic differentiation for this character in <em>Datura stramonium</em>. The results are considered in the light of the adaptive role of leaf trichomes as a component of defence to herbivores, and variable selection among populations.</p></blockquote>
<div>
<p style="padding-left:30px;"><strong>Defensive role of leaf trichomes in resistance to herbivorous insects in <em>Datura stramonium</em>,</strong> <em>Journal of Evolutionary Biology, </em>Volume 14 Issue 3 Page 424-432, May 2001</p>
<p style="padding-left:30px;">
<h2>Conclusions</h2>
<p>Contrary to creationists&#8217; claims, evolutionary theory can in fact very well explain the &#8216;paradox&#8217; that the Jimson Weed has a poisonous seed pod, protected by thorns, understanding that the complex ecologies involve predation by mammals as well as insects, that alkaloid content is a selectable trait in response to insect predation, that alkaloid content extends across the plant, not just the seed pods and that the plant has a variety of defenses against its predators. In addition trichomes have been shown to be selectable defenses against insects and the evolution of thorns to protect the seed pods from predation by mammals may very well have been a simultaneous evolution with alkaloid defenses. While I have yet to do the research into the following area, it is not difficult to imagine how trichome defenses, initially evolved against insect predation and that thorns evolved as an additional protection of the seed pods against predation by larger animals, over time additional defenses came &#8216;on line&#8217; including chemical defenses against insects.</p>
<h2>Other Claims</h2>
<blockquote><p>Its roots, stems and leaves all contain trace amount of natural poisons, including several alkaloid compounds. And yet, the MOST toxic area of the plant is found in the seed pod.</p>
<p>versus</p>
<p>This paper reports a study of the alkaloid content of different parts of Datura stramoniumL. (Solanaceae) in various stages of its growth and development, and the location, structure and ultrastructure of alkaloid-biosynthesizing cells (idioblasts) in different parts of naturally grown and cultured plant material. TLC, HPLC, and GC/MS methods were used for alkaloid assays. The results showed that alkaloid production starts from the end of the second week after seed germination, increases in different organs up to the tenth week of growth, and then decreases. Leaves and capsules showed the highest alkaloid content in the vegetative and generative stages, respectively. In leaves the alkaloids decreased rapidly in the generative stage. The highest alkaloid content was recorded in vegetative leaves, followed in descending order by vegetative petioles, generative and vegetative stems, generative petioles, generative roots, generative leaves, vegetative roots and mature seeds. The organs as well as calli derived from different leaf parts were examined for the presence of idioblasts by microscopic and cytochemical methods. Idioblasts were present only in semi-hyaline callus originated from leaf base; they were spherical or oval, with a thick cell wall and large central vacuole. These observations should prove helpful in attempts to produce specific alkaloids in naturally grown plants and cell cultures.</p></blockquote>
<p>In DISTRIBUTION OF ATROPINE AND SCOPOLAMINE IN DIFFERENT ORGANS  AND STAGES OF DEVELOPMENT IN DATURA STRAMONIUML. (SOLANACEAE). STRUCTURE AND ULTRASTRUCTURE  OF BIOSYNTHESIZING CELLS</p>
<p style="text-align:center;"><img class="aligncenter" style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/picture-2.png?w=540&#038;h=574" alt="Alkaloid contents" width="540" height="574" /></p>
<h2>Other factors</h2>
<p class="first last">
<p class="first last">
<p class="first last"><strong>Evolutionary ecology of Datura stramonium: equal plant fitness benefits of growth and resistance against herbivory.</strong></p>
<blockquote>
<p class="first last"><strong>Abstract:</strong><br />
This study evaluated how natural selection act upon two proposed alternatives of defence (growth and resistance) against natural enemies in a common garden experiment using genetic material (full-sibs) from three populations of the annual plant Datura stramonium. Genetic and phenotypic correlations were used to search for a negative association between both alternatives of defence. Finally, the presence/absence of natural enemies was manipulated to evaluate the selective value of growth as a response against herbivory. Results indicated the presence of genetic variation for growth and resistance (1 &#8211; relative damage), whereas only population differentiation for resistance was detected. No correlation between growth and resistance was detected either at the phenotypic or the genetic level. Selection analysis revealed the presence of equal fitness benefits of growth and resistance among populations. The presence/absence of natural herbivores revealed that herbivory did not alter the pattern of selection on growth. The results indicate that both strategies of defence can evolve simultaneously within populations of D. stramonium.</p>
</blockquote>
</div>
<p>and</p>
<blockquote><p><strong>Abstract:</strong><br />
This study evaluated how natural selection act upon two proposed alternatives of defence (growth and resistance) against natural enemies in a common garden experiment using genetic material (full-sibs) from three populations of the annual plant Datura stramonium. Genetic and phenotypic correlations were used to search for a negative association between both alternatives of defence. Finally, the presence/absence of natural enemies was manipulated to evaluate the selective value of growth as a response against herbivory. Results indicated the presence of genetic variation for growth and resistance (1 &#8211; relative damage), whereas only population differentiation for resistance was detected. No correlation between growth and resistance was detected either at the phenotypic or the genetic level. Selection analysis revealed the presence of equal fitness benefits of growth and resistance among populations. The presence/absence of natural herbivores revealed that herbivory did not alter the pattern of selection on growth. The results indicate that both strategies of defence can evolve simultaneously within populations of D. stramonium.</p></blockquote>
<p class="info">
<div>
<p><em> VALVERDE, P. L. ;  FORNONI, J. ;  NUNEZ-FARFAN, J. </em><strong>Evolutionary ecology of Datura stramonium: equal plant fitness benefits of growth and resistance against herbivory.</strong> Journal of Evolutionary Biology.    16(1):127-137, January 2003.</p>
</div>
<p class="abstract">Now we look at</p>
<p class="abstract">
<div class="art_authors">Juan Núñez-Farfán, Juan Fornoni, Pedro Luis Valverde<span class="art_journal"> </span><strong>The Evolution of Resistance and Tolerance to Herbivores</strong> <span class="art_journal"><em>Annual Review of Ecology, Evolution, and Systematics</em><span>,    <span class="art_dateVolumeIssuePart">December 2007, Vol. 38</span><span class="art_pages">,         Pages 541-566</span></span></span></div>
<div class="abstractSection">
<blockquote>
<p class="first last">Tolerance and resistance are two different plant defense strategies against herbivores. Empirical evidence in natural populations reveals that individual plants allocate resources simultaneously to both strategies, thus plants exhibit a mixed pattern of defense. In this review we examine the conditions that promote the evolutionary stability of mixed defense strategies in the light of available empirical and theoretical evidence. Given that plant tolerance and resistance are heritable and subject to environmentally dependent selection and genetic constraints, the joint evolution of tolerance and resistance is analyzed, with consideration of multiple species interactions and the plant mating system. The existence of mixed defense strategies in plants makes it necessary to re-explore the coevolutionary process between plants and herbivores, which centered historically on resistance as the only defensive mechanism. In addition, we recognize briefly the potential use of plant tolerance for pest management. Finally, we highlight unresolved issues for future development in this field of evolutionary ecology.</p>
<p class="first last">
</blockquote>
<p class="first last">Update 05-22-2008</p>
<p class="first last"><img style="vertical-align:middle;" src="http://idexposed.files.wordpress.com/2008/05/seeds.png?w=523&#038;h=305" alt="" width="523" height="305" /></p>
</div>
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			<media:title type="html">Alkaloid contents</media:title>
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		<title>Behe vs Lampreys: A modest proposal.</title>
		<link>http://idexposed.wordpress.com/2008/05/10/behe-vs-lampreys-a-modest-proposal/</link>
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		<pubDate>Sat, 10 May 2008 15:51:04 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
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		<description><![CDATA[On Panda&#8217;s Thumb, Ian Musgrave shows how by doing hard work science has undermined further, the Irreducible Complexity argument about the blood clotting cascade as proposed by Michael Behe. In fact, the hard work supported a prediction made by Doolittle. Ian challenges ID proponents to finally do some science So I have a modest proposal. [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=17&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p><img class="alignleft" style="float:left;" src="http://pandasthumb.org/images/pt-banner.jpg" alt="" width="120" height="30" />On Panda&#8217;s Thumb, <a href="http://pandasthumb.org/archives/2008/05/behe-vs-lamprey.html">Ian Musgrave shows</a> how by doing hard work science has undermined further, the Irreducible Complexity argument about the blood clotting cascade as proposed by Michael Behe. In fact, the hard work supported a prediction made by Doolittle.</p>
<p>Ian challenges ID proponents to finally do some science</p>
<blockquote><p>So I have a modest proposal. I would like to invite Dr. Behe, or any other ID advocate, to predict which coagulation factors are present in Amphioxus, search the <a rel="external " href="http://genome.jgi-psf.org/Brafl1/Brafl1.home.html" target="_blank">Amphioxus genome database</a> and report on whether the genes found match their predictions. The database is free, you can do it at home, and the only cost is your time.</p>
<p>Time for ID advocates to do some science. How about it?</p></blockquote>
<p>Any Takers?</p>
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		<title>Kenneth R. Miller The Boston Globe &#8220;Trouble ahead for science&#8221;</title>
		<link>http://idexposed.wordpress.com/2008/05/08/kenneth-r-miller-the-boston-globe-trouble-ahead-for-science/</link>
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		<pubDate>Thu, 08 May 2008 15:58:52 +0000</pubDate>
		<dc:creator>idexposed</dc:creator>
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		<description><![CDATA[Ken Miller in a May 8 OpEd the Boston Globe writes about &#8220;Expelled&#8221;: Why is all this nonsense a threat to science? The reason is Stein&#8217;s libelous conclusion that science is simply evil. In an April 21 interview on the Trinity Broadcast Network, Stein called the Nazi murder of children &#8220;horrifying beyond words.&#8221; Indeed. But [...]<img alt="" border="0" src="http://stats.wordpress.com/b.gif?host=idexposed.wordpress.com&amp;blog=3645162&amp;post=16&amp;subd=idexposed&amp;ref=&amp;feed=1" width="1" height="1" />]]></description>
			<content:encoded><![CDATA[<p><img class="alignleft" style="float:left;" src="http://pandasthumb.org/archives/banner-thumb-125x35.jpg" alt="Expelled Exposed" width="125" height="35" />Ken Miller in a <a href="http://www.boston.com/bostonglobe/editorial_opinion/oped/articles/2008/05/08/trouble_ahead_for_science/" target="_blank">May 8 OpEd</a> the Boston Globe writes about &#8220;Expelled&#8221;:</p>
<blockquote><p>Why is all this nonsense a threat to science? The reason is Stein&#8217;s libelous conclusion that science is simply evil. In an April 21 interview on the Trinity Broadcast Network, Stein called the Nazi murder of children &#8220;horrifying beyond words.&#8221; Indeed. But what led to such horrors? Stein explained: &#8220;that&#8217;s where science in my opinion, this is just an opinion, that&#8217;s where science leads you. Love of God and compassion and empathy leads you to a very glorious place. Science leads you to killing people.&#8221;</p>
<p>According to Stein, science leads you to &#8220;killing people.&#8221; Not to cures and vaccines, not to a deeper understanding of nature, not to wonders like computers and cellphones, and certainly not to a better life. Nope. Science is murder.</p>
<p>&#8220;Expelled&#8221; is a shoddy piece of propaganda that props up the failures of Intelligent Design by playing the victim card. It deceives its audiences, slanders the scientific community, and contributes mightily to a climate of hostility to science itself. Stein is doing nothing less than helping turn a generation of American youth away from science. If we actually come to believe that science leads to murder, then we deserve to lose world leadership in science. In that sense, the word &#8220;expelled&#8221; may have a different and more tragic connotation for our country than Stein intended.</p></blockquote>
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